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1.
Article | IMSEAR | ID: sea-203806

ABSTRACT

The concept of beauty and cosmetic is an ancient as mankind and civilization. The word‘COSMETIC’ was derived from the Greek word “KOSM TIKAS “meaning having the power, arrange, skillin decorating. In starting with 1990, some cosmetic manufacturer company claims that addition ofsome plant based active ingredient, therapeutically benefit to describe the OTC skin care products, suchas alpha – hydroxy acid, retinoic acid, ascorbic acid and coenzyme. The herbal cosmetic is thepreparations containing phytochemical from a botanical source, which influence the function of skinand provide nutrients necessary for the healthy skin and hair. The beauty of skin and hair depends uponsome facts such as – healthy habits, climatic conditions, routine job and maintenance. In front ofmirror, we don’t recognize ourselves, in compare to 10 years back. Dark circles under the eyes,pigmentation, wrinkles – all of these indicate our aging problems. There is some small basic step thatyou can follow everyday of your life – the ‘CTM’ process. This CTM process not only applicable for theone who has the aging problem, but also applicable for all the ages of public both man and woman. Likeany other branch of science and technology, present scenario of herbal medicines has its own limitationarising out of its own technical constituents. Coconut oil is good for especially dry skin. Some commontriggers for hair fall – genetic, hormonal, stress, medications, Immunity, Radiation, Tight Hairdos.Bhringraj; it promotes hair growth, prevents hair fall, treat damaged hair and strengthens hair follicles.An itchy scalp and flakiness are the hallmark signs of dandruff, but it may also cause other symptomslike greasy patches on the scalp and tingling skin. Neem; it stimulates hair growth, promotes scalphealthy and act as an anti-bacterial. Stop taking an herb if any side effect develops such as allergy,stomach upset, skin rash or headache.

2.
Article | IMSEAR | ID: sea-203803

ABSTRACT

There are multiple issues with setting up new diagnostic testing capacity outside ofregular diagnostic laboratories. This is not an overnight solution. Research laboratories havedifferent approaches, equipment and staff. There are multiple steps to ensure that themethods used and results are a correctly validated, as there is nothing more dangerous at themoment than reporting incorrect negative or positive results to staff or patients. That beingsaid we can adapt and validate assays and make them work using our equipment that can thenbe rolled out to support the NHS. PCR is a method widely used to rapidly make millions tobillions of copies of a specific DNA sample, allowing scientists to take a very small sample ofDNA and amplify it to a large enough amount to study in detail. It is fundamental too much ofgenetic testing including analysis of ancient samples of DNA and identification of infectiousagents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplifiedin a series of cycles of temperature changes. PCR is now a common and often indispensabletechnique used in medical laboratory and clinical laboratory research for a broad variety ofapplications including biomedical research and criminal forensics.

3.
Article in English | IMSEAR | ID: sea-151322

ABSTRACT

In the present investigation, our aim of synthesis is to find a molecule having multi drug treatment means the drug which resists the inflammation produce due to microbial infection. So, 2,4,5-triphenyl-1H-imidazole-1-yl derivatives were synthesized and tested for their antiinflammatory activity in-vitro using Phenylbutazone as a reference drug and antimicrobial activity using clotrimazole and ciprofloxacin as a standard drug. Compound 6b was found to be the most potent derivative of the series.

4.
Article in English | IMSEAR | ID: sea-150821

ABSTRACT

Pyrimidine plays a significant role among other heterocycles. From the literature survey, in recent years the design of 3,4-dihydropyrimidin-2(1H)-ones nucleus have been attracted for considerable interest because of their therapeutic and pharmacological properties. Pyrimidine nucleus was synthesized by Biginelli reaction. This product was subjected for alkaline ester hydrolysis and these derivatives on treatment with thionyl chloride and substitution by different secondary amines produced final desired compounds. The remaining compounds have been synthesized by above method. The purity of the compounds has been checked by TLC monitoring and the conformation of structure was confirmed by different spectra like UV, IR, NMR, Mass etc. The in-vitro antihypertensive and calcium channel blocking activity have been done by IC50 measurement method with nifedipine as standard.

5.
Article in English | IMSEAR | ID: sea-150797

ABSTRACT

In the present investigation, a series of some synthesis and biological evaluation of some pyrazolone derivatives with imidazole, benzimidazole and benztriazole moiety were synthesized and tested for their anti-inflammatory activity in-vitro using celecoxib as a reference drug. Compound 8d was found to be the most potent derivative of the series with 75 %inhibition of inflammation.

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